GC can activate PPARc in MSCs through different pathways to promote adipogenesis, which reduces osteoblast differentiation, and eventually leads CP-690550 JAK inhibitor
to fat tissue accumulation in bone marrow. Taken together, these studies suggest that the GIO bone loss is comprised of multiple mechanisms involving the increase in bone marrow adipogenesis and decrease in marrow angiogenesis leading to a decrease in bone marrow microvasculature and consequent decrease in osteogenesis. Salvia miltiorrhiza Bunge is a traditional Chinese medicine, called danshen, widely used in clinical practice for Torin 1 mTOR inhibitor
the prevention and treatment of cardio-cerebral vascular diseases. Pharmacological testing showed that danshen has anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, mitochondrial protective and other activities.